BDBM50343793 CHEMBL1774535::N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-fluorobutyl)-1H-indole-2-carboxamide

SMILES: FC(CCNC(=O)c1cc2ccccc2[nH]1)CN1CCN(CC1)c1cccc(Cl)c1Cl

InChI Key: InChIKey=VIHBCLOGDPFGGP-UHFFFAOYSA-N

Data: 5 KI  2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50343793   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50343793 (CHEMBL1774535 | N-(4-(4-(2,3-Dichlorophenyl)pipera...) Show SMILES FC(CCNC(=O)c1cc2ccccc2[nH]1)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C23H25Cl2FN4O/c24-18-5-3-7-21(22(18)25)30-12-10-29(11-13-30)15-17(26)8-9-27-23(31)20-14-16-4-1-2-6-19(16)28-20/h1-7,14,17,28H,8-13,15H2,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [125I]-IABN from human dopamine D3 receptor expressed in HEK293 cells after 60 mins by gamma counting				J Med Chem 54: 3581-94 (2011) Article DOI: 10.1021/jm200288r BindingDB Entry DOI: 10.7270/Q25M661K
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50343793 (CHEMBL1774535 | N-(4-(4-(2,3-Dichlorophenyl)pipera...) Show SMILES FC(CCNC(=O)c1cc2ccccc2[nH]1)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C23H25Cl2FN4O/c24-18-5-3-7-21(22(18)25)30-12-10-29(11-13-30)15-17(26)8-9-27-23(31)20-14-16-4-1-2-6-19(16)28-20/h1-7,14,17,28H,8-13,15H2,(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	212	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [125I]DOI from 5HT2A receptor				J Med Chem 54: 3581-94 (2011) Article DOI: 10.1021/jm200288r BindingDB Entry DOI: 10.7270/Q25M661K
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50343793 (CHEMBL1774535 | N-(4-(4-(2,3-Dichlorophenyl)pipera...) Show SMILES FC(CCNC(=O)c1cc2ccccc2[nH]1)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C23H25Cl2FN4O/c24-18-5-3-7-21(22(18)25)30-12-10-29(11-13-30)15-17(26)8-9-27-23(31)20-14-16-4-1-2-6-19(16)28-20/h1-7,14,17,28H,8-13,15H2,(H,27,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	223	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from 5HT1A receptor				J Med Chem 54: 3581-94 (2011) Article DOI: 10.1021/jm200288r BindingDB Entry DOI: 10.7270/Q25M661K
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50343793 (CHEMBL1774535 | N-(4-(4-(2,3-Dichlorophenyl)pipera...) Show SMILES FC(CCNC(=O)c1cc2ccccc2[nH]1)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C23H25Cl2FN4O/c24-18-5-3-7-21(22(18)25)30-12-10-29(11-13-30)15-17(26)8-9-27-23(31)20-14-16-4-1-2-6-19(16)28-20/h1-7,14,17,28H,8-13,15H2,(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	526	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [125I]-IABN from human dopamine D2L receptor expressed in HEK293 cells after 60 mins by gamma counting				J Med Chem 54: 3581-94 (2011) Article DOI: 10.1021/jm200288r BindingDB Entry DOI: 10.7270/Q25M661K
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50343793 (CHEMBL1774535 | N-(4-(4-(2,3-Dichlorophenyl)pipera...) Show SMILES FC(CCNC(=O)c1cc2ccccc2[nH]1)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C23H25Cl2FN4O/c24-18-5-3-7-21(22(18)25)30-12-10-29(11-13-30)15-17(26)8-9-27-23(31)20-14-16-4-1-2-6-19(16)28-20/h1-7,14,17,28H,8-13,15H2,(H,27,31)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.36E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [125I]-IABN from human dopamine D4 receptor expressed in HEK293 cells after 60 mins by gamma counting				J Med Chem 54: 3581-94 (2011) Article DOI: 10.1021/jm200288r BindingDB Entry DOI: 10.7270/Q25M661K
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50343793 (CHEMBL1774535 | N-(4-(4-(2,3-Dichlorophenyl)pipera...) Show SMILES FC(CCNC(=O)c1cc2ccccc2[nH]1)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C23H25Cl2FN4O/c24-18-5-3-7-21(22(18)25)30-12-10-29(11-13-30)15-17(26)8-9-27-23(31)20-14-16-4-1-2-6-19(16)28-20/h1-7,14,17,28H,8-13,15H2,(H,27,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.14E+3	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding				J Med Chem 54: 3581-94 (2011) Article DOI: 10.1021/jm200288r BindingDB Entry DOI: 10.7270/Q25M661K
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50343793 (CHEMBL1774535 | N-(4-(4-(2,3-Dichlorophenyl)pipera...) Show SMILES FC(CCNC(=O)c1cc2ccccc2[nH]1)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C23H25Cl2FN4O/c24-18-5-3-7-21(22(18)25)30-12-10-29(11-13-30)15-17(26)8-9-27-23(31)20-14-16-4-1-2-6-19(16)28-20/h1-7,14,17,28H,8-13,15H2,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2...				J Med Chem 54: 3581-94 (2011) Article DOI: 10.1021/jm200288r BindingDB Entry DOI: 10.7270/Q25M661K
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50343793 (CHEMBL1774535 | N-(4-(4-(2,3-Dichlorophenyl)pipera...) Show SMILES FC(CCNC(=O)c1cc2ccccc2[nH]1)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C23H25Cl2FN4O/c24-18-5-3-7-21(22(18)25)30-12-10-29(11-13-30)15-17(26)8-9-27-23(31)20-14-16-4-1-2-6-19(16)28-20/h1-7,14,17,28H,8-13,15H2,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	520	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinopirole-induced mitogenisis				J Med Chem 54: 3581-94 (2011) Article DOI: 10.1021/jm200288r BindingDB Entry DOI: 10.7270/Q25M661K
					More data for this Ligand-Target Pair