BDBM50343888 (R)-4-(4-(2,2-difluoro-1-hydroxyethyl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid::CHEMBL1774903
SMILES: O[C@@H](C(F)F)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O
InChI Key: InChIKey=PLNKQIULCCRLIX-HSZRJFAPSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P2Y purinoceptor 14 (Mus musculus) | BDBM50343888 ((R)-4-(4-(2,2-difluoro-1-hydroxyethyl)phenyl)-7-(4...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of mouse P2Y14 receptor | Eur J Med Chem 175: 34-39 (2019) Article DOI: 10.1016/j.ejmech.2019.04.068 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2Y purinoceptor 14 (Mus musculus) | BDBM50343888 ((R)-4-(4-(2,2-difluoro-1-hydroxyethyl)phenyl)-7-(4...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of mouse P2Y14 receptor in presence of 2% HSA | Eur J Med Chem 175: 34-39 (2019) Article DOI: 10.1016/j.ejmech.2019.04.068 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2Y purinoceptor 14 (Mus musculus) | BDBM50343888 ((R)-4-(4-(2,2-difluoro-1-hydroxyethyl)phenyl)-7-(4...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem Lett 21: 2836-9 (2011) Article DOI: 10.1016/j.bmcl.2011.03.081 BindingDB Entry DOI: 10.7270/Q2NP24S4 | |||||||||||
More data for this Ligand-Target Pair |