BDBM50344026 CHEMBL1780111::trans-(3R,5R)-N-((6-aminopyridin-2-yl)methyl)-5-ethyl-1-((5-methyl-2-phenyloxazol-4-yl)methyl)piperidine-3-carboxamide

SMILES: CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(N)n1

InChI Key: InChIKey=UIMPAJVJPBIYQJ-UYAOXDASSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50344026   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (Homo sapiens (Human))	BDBM50344026 (CHEMBL1780111 | trans-(3R,5R)-N-((6-aminopyridin-2...) Show SMILES CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(N)n1 |r| Show InChI InChI=1S/C25H31N5O2/c1-3-18-12-20(24(31)27-13-21-10-7-11-23(26)28-21)15-30(14-18)16-22-17(2)32-25(29-22)19-8-5-4-6-9-19/h4-11,18,20H,3,12-16H2,1-2H3,(H2,26,28)(H,27,31)/t18-,20-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.42	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PDE8B				Bioorg Med Chem Lett 21: 3095-8 (2011) Article DOI: 10.1016/j.bmcl.2011.03.022 BindingDB Entry DOI: 10.7270/Q20002F8
					More data for this Ligand-Target Pair