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SMILES: CCOc1cccc2cc(-c3ccc(OC)cc3)c(=O)oc12
InChI Key: InChIKey=MZYDUIAIVPQMQY-UHFFFAOYSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adenosine receptor A3 (Homo sapiens (Human)) | BDBM50344057 (8-Ethoxy-3-(4'-methoxyphenyl)coumarin | CHEMBL1777...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 258 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113907 BindingDB Entry DOI: 10.7270/Q20K2DJC | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adenosine receptor A3 (Homo sapiens (Human)) | BDBM50344057 (8-Ethoxy-3-(4'-methoxyphenyl)coumarin | CHEMBL1777...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Porto Curated by ChEMBL | Assay Description Displacement of [3H]HEMADO from human adenosine receptor A3 expressed in CHO cell membranes by radioligand competition assay | J Med Chem 63: 2577-2587 (2020) Article DOI: 10.1021/acs.jmedchem.9b01572 BindingDB Entry DOI: 10.7270/Q23B63JP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adenosine receptor A2b (Homo sapiens (Human)) | BDBM50344057 (8-Ethoxy-3-(4'-methoxyphenyl)coumarin | CHEMBL1777...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Porto Curated by ChEMBL | Assay Description Displacement of radioligand from human adenosine receptor A2B expressed in CHO cell membranes by radioligand competition assay | J Med Chem 63: 2577-2587 (2020) Article DOI: 10.1021/acs.jmedchem.9b01572 BindingDB Entry DOI: 10.7270/Q23B63JP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adenosine receptor A2a (Homo sapiens (Human)) | BDBM50344057 (8-Ethoxy-3-(4'-methoxyphenyl)coumarin | CHEMBL1777...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Porto Curated by ChEMBL | Assay Description Displacement of [3H]NECA from human adenosine receptor A2A expressed in CHO cell membranes by radioligand competition assay | J Med Chem 63: 2577-2587 (2020) Article DOI: 10.1021/acs.jmedchem.9b01572 BindingDB Entry DOI: 10.7270/Q23B63JP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adenosine receptor A1 (Homo sapiens (Human)) | BDBM50344057 (8-Ethoxy-3-(4'-methoxyphenyl)coumarin | CHEMBL1777...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Porto Curated by ChEMBL | Assay Description Displacement of [3H]CCPA from human adenosine receptor A1 expressed in CHO cell membranes by radioligand competition assay | J Med Chem 63: 2577-2587 (2020) Article DOI: 10.1021/acs.jmedchem.9b01572 BindingDB Entry DOI: 10.7270/Q23B63JP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Polyphenol oxidase 2 (Agaricus bisporus (Common mushroom)) | BDBM50344057 (8-Ethoxy-3-(4'-methoxyphenyl)coumarin | CHEMBL1777...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Santiago de Compostela Curated by ChEMBL | Assay Description Inhibition of mushroom tyrosinase using L-3,4- dihydroxyphenylalanine as substrate measured for 5 mins by spectrophotometric analysis | Bioorg Med Chem Lett 21: 3342-5 (2011) Article DOI: 10.1016/j.bmcl.2011.04.012 BindingDB Entry DOI: 10.7270/Q2QF8T68 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adenosine receptor A3 (Homo sapiens (Human)) | BDBM50344057 (8-Ethoxy-3-(4'-methoxyphenyl)coumarin | CHEMBL1777...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Porto Curated by ChEMBL | Assay Description Antagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Gl... | J Med Chem 63: 2577-2587 (2020) Article DOI: 10.1021/acs.jmedchem.9b01572 BindingDB Entry DOI: 10.7270/Q23B63JP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adenosine receptor A2b (Homo sapiens (Human)) | BDBM50344057 (8-Ethoxy-3-(4'-methoxyphenyl)coumarin | CHEMBL1777...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Porto Curated by ChEMBL | Assay Description Antagonist activity at human adenosine receptor A2B expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by G... | J Med Chem 63: 2577-2587 (2020) Article DOI: 10.1021/acs.jmedchem.9b01572 BindingDB Entry DOI: 10.7270/Q23B63JP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
