BDBM50344128 CHEMBL1778185::[6-(2,4-Difluoro-phenoxy)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-(1,1-dioxo-hexahydro-1lambda*6*-thiopyran-4-yl)-amine

SMILES: Fc1ccc(Oc2ncc3c(NC4CCS(=O)(=O)CC4)[nH]nc3n2)c(F)c1

InChI Key: InChIKey=RSNJGADWQQUYPJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50344128   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50344128 (CHEMBL1778185 | [6-(2,4-Difluoro-phenoxy)-1H-pyraz...) Show SMILES Fc1ccc(Oc2ncc3c(NC4CCS(=O)(=O)CC4)[nH]nc3n2)c(F)c1 Show InChI InChI=1S/C16H15F2N5O3S/c17-9-1-2-13(12(18)7-9)26-16-19-8-11-14(22-23-15(11)21-16)20-10-3-5-27(24,25)6-4-10/h1-2,7-8,10H,3-6H2,(H2,19,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic protein				Bioorg Med Chem Lett 21: 3452-6 (2011) Article DOI: 10.1016/j.bmcl.2011.03.098 BindingDB Entry DOI: 10.7270/Q26H4HR7
					More data for this Ligand-Target Pair