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BDBM50344675 6-chloro-4-((5-(5-chloropyridin-2-yl)-4-(3,3,3-trifluoropropyl)-4H-1,2,4-triazol-3-yl)methyl)-8-nitro-2H-benzo[b][1,4]oxazin-3(4H)-one::CHEMBL1779223

SMILES: [O-][N+](=O)c1cc(Cl)cc2N(Cc3nnc(-c4ccc(Cl)cn4)n3CCC(F)(F)F)C(=O)COc12

InChI Key: InChIKey=CYGGWTOVNXMRNL-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50344675   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344675
PNG
(6-chloro-4-((5-(5-chloropyridin-2-yl)-4-(3,3,3-tri...)
Show SMILES [O-][N+](=O)c1cc(Cl)cc2N(Cc3nnc(-c4ccc(Cl)cn4)n3CCC(F)(F)F)C(=O)COc12
Show InChI InChI=1S/C19H13Cl2F3N6O4/c20-10-1-2-12(25-7-10)18-27-26-15(28(18)4-3-19(22,23)24)8-29-13-5-11(21)6-14(30(32)33)17(13)34-9-16(29)31/h1-2,5-7H,3-4,8-9H2
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Similars
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair