BDBM50344688 8-amino-6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-trifluoropropyl)-4H-1,2,4-triazol-3-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one::CHEMBL1779205

SMILES: Nc1cc(Cl)cc2N(Cc3nnc(CCc4ccc(Cl)cc4)n3CCC(F)(F)F)C(=O)COc12

InChI Key: InChIKey=HWWOXEMWIWNSPE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50344688   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50344688 (8-amino-6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,...) Show SMILES Nc1cc(Cl)cc2N(Cc3nnc(CCc4ccc(Cl)cc4)n3CCC(F)(F)F)C(=O)COc12 Show InChI InChI=1S/C22H20Cl2F3N5O2/c23-14-4-1-13(2-5-14)3-6-18-29-30-19(31(18)8-7-22(25,26)27)11-32-17-10-15(24)9-16(28)21(17)34-12-20(32)33/h1-2,4-5,9-10H,3,6-8,11-12,28H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...				Bioorg Med Chem Lett 21: 3774-9 (2011) Article DOI: 10.1016/j.bmcl.2011.04.053 BindingDB Entry DOI: 10.7270/Q2KK9C32
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