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BDBM50344690 CHEMBL1779207::N-(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-trifluoropropyl)-4H-1,2,4-triazol-3-yl)methyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)-N-(methylsulfonyl)methanesulfonamide

SMILES: CS(=O)(=O)N(c1cc(Cl)cc2N(Cc3nnc(CCc4ccc(Cl)cc4)n3CCC(F)(F)F)C(=O)COc12)S(C)(=O)=O

InChI Key: InChIKey=CUFDFHMLBZXTGU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50344690   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344690
PNG
(CHEMBL1779207 | N-(6-chloro-4-((5-(4-chloropheneth...)
Show SMILES CS(=O)(=O)N(c1cc(Cl)cc2N(Cc3nnc(CCc4ccc(Cl)cc4)n3CCC(F)(F)F)C(=O)COc12)S(C)(=O)=O
Show InChI InChI=1S/C24H24Cl2F3N5O6S2/c1-41(36,37)34(42(2,38)39)19-12-17(26)11-18-23(19)40-14-22(35)33(18)13-21-31-30-20(32(21)10-9-24(27,28)29)8-5-15-3-6-16(25)7-4-15/h3-4,6-7,11-12H,5,8-10,13-14H2,1-2H3
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PubMed
n/an/a 21n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair