BDBM50344726 2'-(2-(5-methoxypyridin-3-yl)pyrimidin-4-yl)-5',6'-dihydrospiro[piperidine-4,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one::CHEMBL1779363

SMILES: COc1cncc(c1)-c1nccc(n1)-c1cc2c([nH]1)C1(CCNCC1)CNC2=O

InChI Key: InChIKey=LRQYWJHBWMMKCY-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50344726   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50344726 (2'-(2-(5-methoxypyridin-3-yl)pyrimidin-4-yl)-5',6'...) Show SMILES COc1cncc(c1)-c1nccc(n1)-c1cc2c([nH]1)C1(CCNCC1)CNC2=O Show InChI InChI=1S/C21H22N6O2/c1-29-14-8-13(10-23-11-14)19-24-5-2-16(27-19)17-9-15-18(26-17)21(12-25-20(15)28)3-6-22-7-4-21/h2,5,8-11,22,26H,3-4,6-7,12H2,1H3,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.90	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MK2 pretreated for 30 mins before fluorescein labeled substrate peptide addition measured after 2 hrs by IMAP assay				Bioorg Med Chem Lett 21: 3823-7 (2011) Article DOI: 10.1016/j.bmcl.2011.04.016 BindingDB Entry DOI: 10.7270/Q2FT8MCB
					More data for this Ligand-Target Pair