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SMILES: FC(F)(F)c1ccc(Nc2cc(Cl)nc3ncnn23)cc1

InChI Key: InChIKey=JNIXLHUITKSWMS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50345436   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM50345436 (5-Chloro-N-(4-trifluoromethyl)phenyl)-[1,2,4]triaz...) Show SMILES FC(F)(F)c1ccc(Nc2cc(Cl)nc3ncnn23)cc1 Show InChI InChI=1S/C12H7ClF3N5/c13-9-5-10(21-11(20-9)17-6-18-21)19-8-3-1-7(2-4-8)12(14,15)16/h1-6,19H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Inhibition of His6-tagged recombinant human dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as substrate after 10 t...				J Med Chem 54: 3935-49 (2011) Article DOI: 10.1021/jm200265b BindingDB Entry DOI: 10.7270/Q2FN16HS
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum)	BDBM50345436 (5-Chloro-N-(4-trifluoromethyl)phenyl)-[1,2,4]triaz...) Show SMILES FC(F)(F)c1ccc(Nc2cc(Cl)nc3ncnn23)cc1 Show InChI InChI=1S/C12H7ClF3N5/c13-9-5-10(21-11(20-9)17-6-18-21)19-8-3-1-7(2-4-8)12(14,15)16/h1-6,19H	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...				J Med Chem 54: 3935-49 (2011) Article DOI: 10.1021/jm200265b BindingDB Entry DOI: 10.7270/Q2FN16HS
					More data for this Ligand-Target Pair