BDBM50345529 CHEMBL1784354::N-(1-(4-(4-fluorophenyl)piperazin-1-ylsulfonyl)-2-methylpropan-2-yl)-N-hydroxyformamide

SMILES: CC(C)(CS(=O)(=O)N1CCN(CC1)c1ccc(F)cc1)N(O)C=O

InChI Key: InChIKey=JKTGELXOMXEKJI-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50345529   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-14 (MMP14) (Homo sapiens (Human))	BDBM50345529 (CHEMBL1784354 | N-(1-(4-(4-fluorophenyl)piperazin-...) Show SMILES CC(C)(CS(=O)(=O)N1CCN(CC1)c1ccc(F)cc1)N(O)C=O Show InChI InChI=1S/C15H22FN3O4S/c1-15(2,19(21)12-20)11-24(22,23)18-9-7-17(8-10-18)14-5-3-13(16)4-6-14/h3-6,12,21H,7-11H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant human MMP-14 assessed as substrate cleavage after 20 hrs by fluorescence assay				Bioorg Med Chem Lett 21: 3301-6 (2011) Article DOI: 10.1016/j.bmcl.2011.04.028 BindingDB Entry DOI: 10.7270/Q2P55NVH
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) (Homo sapiens (Human))	BDBM50345529 (CHEMBL1784354 | N-(1-(4-(4-fluorophenyl)piperazin-...) Show SMILES CC(C)(CS(=O)(=O)N1CCN(CC1)c1ccc(F)cc1)N(O)C=O Show InChI InChI=1S/C15H22FN3O4S/c1-15(2,19(21)12-20)11-24(22,23)18-9-7-17(8-10-18)14-5-3-13(16)4-6-14/h3-6,12,21H,7-11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assay				Bioorg Med Chem Lett 21: 3301-6 (2011) Article DOI: 10.1016/j.bmcl.2011.04.028 BindingDB Entry DOI: 10.7270/Q2P55NVH
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50345529 (CHEMBL1784354 | N-(1-(4-(4-fluorophenyl)piperazin-...) Show SMILES CC(C)(CS(=O)(=O)N1CCN(CC1)c1ccc(F)cc1)N(O)C=O Show InChI InChI=1S/C15H22FN3O4S/c1-15(2,19(21)12-20)11-24(22,23)18-9-7-17(8-10-18)14-5-3-13(16)4-6-14/h3-6,12,21H,7-11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of CYP3A4				Bioorg Med Chem Lett 21: 3301-6 (2011) Article DOI: 10.1016/j.bmcl.2011.04.028 BindingDB Entry DOI: 10.7270/Q2P55NVH
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50345529 (CHEMBL1784354 | N-(1-(4-(4-fluorophenyl)piperazin-...) Show SMILES CC(C)(CS(=O)(=O)N1CCN(CC1)c1ccc(F)cc1)N(O)C=O Show InChI InChI=1S/C15H22FN3O4S/c1-15(2,19(21)12-20)11-24(22,23)18-9-7-17(8-10-18)14-5-3-13(16)4-6-14/h3-6,12,21H,7-11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant human MMP-1 assessed as substrate cleavage after 20 hrs by fluorescence assay				Bioorg Med Chem Lett 21: 3301-6 (2011) Article DOI: 10.1016/j.bmcl.2011.04.028 BindingDB Entry DOI: 10.7270/Q2P55NVH
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50345529 (CHEMBL1784354 | N-(1-(4-(4-fluorophenyl)piperazin-...) Show SMILES CC(C)(CS(=O)(=O)N1CCN(CC1)c1ccc(F)cc1)N(O)C=O Show InChI InChI=1S/C15H22FN3O4S/c1-15(2,19(21)12-20)11-24(22,23)18-9-7-17(8-10-18)14-5-3-13(16)4-6-14/h3-6,12,21H,7-11H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant human MMP-13 assessed as substrate cleavage after 20 hrs by fluorescence assay				Bioorg Med Chem Lett 21: 3301-6 (2011) Article DOI: 10.1016/j.bmcl.2011.04.028 BindingDB Entry DOI: 10.7270/Q2P55NVH
					More data for this Ligand-Target Pair