BDBM50345550 3-(2-(2-Methylthiazol-4-yl)ethynyl)-5-nitrobenzonitrile::CHEMBL1784540
SMILES: Cc1nc(cs1)C#Cc1cc(cc(c1)[N+]([O-])=O)C#N
InChI Key: InChIKey=NYDDBVSTHZVPKD-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor (Rattus norvegicus (Rat)) | BDBM50345550 (3-(2-(2-Methylthiazol-4-yl)ethynyl)-5-nitrobenzoni...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Neurodegenerative Disorders Curated by ChEMBL | Assay Description Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation counting | Bioorg Med Chem Lett 21: 3243-7 (2011) Article DOI: 10.1016/j.bmcl.2011.04.047 BindingDB Entry DOI: 10.7270/Q290244M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor (Rattus norvegicus (Rat)) | BDBM50345550 (3-(2-(2-Methylthiazol-4-yl)ethynyl)-5-nitrobenzoni...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.63 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Neurodegenerative Disorders Curated by ChEMBL | Assay Description Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization | Bioorg Med Chem Lett 21: 3243-7 (2011) Article DOI: 10.1016/j.bmcl.2011.04.047 BindingDB Entry DOI: 10.7270/Q290244M | |||||||||||
More data for this Ligand-Target Pair |