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SMILES: Cc1cccc(n1)C#Cc1cc(Br)cc(c1)[N+]([O-])=O

InChI Key: InChIKey=GCSNBRLVXIFCQI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50345560   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50345560
PNG
(3-(2-(6-methylpyridin-2-yl)ethynyl)-5-nitrobromobe...)
Show SMILES Cc1cccc(n1)C#Cc1cc(Br)cc(c1)[N+]([O-])=O
Show InChI InChI=1S/C14H9BrN2O2/c1-10-3-2-4-13(16-10)6-5-11-7-12(15)9-14(8-11)17(18)19/h2-4,7-9H,1H3
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MMDB

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Article
PubMed
n/an/a 0.630n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization

Bioorg Med Chem Lett 21: 3243-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.047
BindingDB Entry DOI: 10.7270/Q290244M
More data for this
Ligand-Target Pair