BDBM50345571 3-(2-(pyridin-2-yl)ethynyl)-5-chlorobenzonitrile::CHEMBL1784617

SMILES: Clc1cc(cc(c1)C#Cc1ccccn1)C#N

InChI Key: InChIKey=ROJRIPXOEQUZDO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50345571   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50345571 (3-(2-(pyridin-2-yl)ethynyl)-5-chlorobenzonitrile |...) Show SMILES Clc1cc(cc(c1)C#Cc1ccccn1)C#N Show InChI InChI=1S/C14H7ClN2/c15-13-8-11(7-12(9-13)10-16)4-5-14-3-1-2-6-17-14/h1-3,6-9H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.03	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Neurodegenerative Disorders Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization				Bioorg Med Chem Lett 21: 3243-7 (2011) Article DOI: 10.1016/j.bmcl.2011.04.047 BindingDB Entry DOI: 10.7270/Q290244M
					More data for this Ligand-Target Pair