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SMILES: COc1ccccc1CNC(=O)c1nc(-c2ccc(F)cc2)n(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c1C1CC1

InChI Key: InChIKey=SOEKQCPJQWCKDC-FGZHOGPDSA-M

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50346284   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50346284
PNG
(CHEMBL1782557 | sodium(3R,5R)-7-(5-cyclopropyl-2-(...)
Show SMILES COc1ccccc1CNC(=O)c1nc(-c2ccc(F)cc2)n(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c1C1CC1 |r|
Show InChI InChI=1S/C28H32FN3O6/c1-38-23-5-3-2-4-19(23)16-30-28(37)25-26(17-6-7-17)32(13-12-21(33)14-22(34)15-24(35)36)27(31-25)18-8-10-20(29)11-9-18/h2-5,8-11,17,21-22,33-34H,6-7,12-16H2,1H3,(H,30,37)(H,35,36)/p-1/t21-,22-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrat...

Bioorg Med Chem Lett 21: 2725-31 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.103
BindingDB Entry DOI: 10.7270/Q2H995J1
More data for this
Ligand-Target Pair