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SMILES: Cc1ccc(CNC(=O)c2nc(-c3ccc(F)cc3)n(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c2C2CC2)cc1F

InChI Key: InChIKey=KHZBSXDYISGQDC-FGZHOGPDSA-M

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50346290   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50346290
PNG
(CHEMBL1782562 | sodium(3R,5R)-7-(5-cyclopropyl-4-(...)
Show SMILES Cc1ccc(CNC(=O)c2nc(-c3ccc(F)cc3)n(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c2C2CC2)cc1F |r|
Show InChI InChI=1S/C28H31F2N3O5/c1-16-2-3-17(12-23(16)30)15-31-28(38)25-26(18-4-5-18)33(11-10-21(34)13-22(35)14-24(36)37)27(32-25)19-6-8-20(29)9-7-19/h2-3,6-9,12,18,21-22,34-35H,4-5,10-11,13-15H2,1H3,(H,31,38)(H,36,37)/p-1/t21-,22-/m1/s1
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MMDB

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PubMed
n/an/a 4.10n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrat...

Bioorg Med Chem Lett 21: 2725-31 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.103
BindingDB Entry DOI: 10.7270/Q2H995J1
More data for this
Ligand-Target Pair