BDBM50346973 CHEMBL1795887

SMILES: CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2[nH]ccc2c1

InChI Key: InChIKey=MZOSYRNVTPEWRZ-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50346973   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (mTOR) (Mus musculus (Mouse))	BDBM50346973 (CHEMBL1795887) Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2[nH]ccc2c1 Show InChI InChI=1S/C39H34N6O2/c1-24-19-32(9-10-33(24)25-3-5-26(6-4-25)39(47)43-31-14-17-44(2)18-15-31)45-36(46)12-8-29-22-41-35-11-7-27(21-34(35)37(29)45)30-20-28-13-16-40-38(28)42-23-30/h3-13,16,19-23,31H,14-15,17-18H2,1-2H3,(H,40,42)(H,43,47)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair