BDBM50346974 CHEMBL1795888

SMILES: CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C)-n1c2c(ccc1=O)cnc1ccccc21

InChI Key: InChIKey=MATRGKSONAFFOH-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50346974   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (mTOR) (Mus musculus (Mouse))	BDBM50346974 (CHEMBL1795888) Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C)-n1c2c(ccc1=O)cnc1ccccc21 Show InChI InChI=1S/C32H30N4O2/c1-21-19-26(36-30(37)14-11-24-20-33-29-6-4-3-5-28(29)31(24)36)12-13-27(21)22-7-9-23(10-8-22)32(38)34-25-15-17-35(2)18-16-25/h3-14,19-20,25H,15-18H2,1-2H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair