BDBM50346975 CHEMBL1795889

SMILES: CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1ccc(N)nc1

InChI Key: InChIKey=DGZPYPBUJVSRMZ-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50346975   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (mTOR) (Mus musculus (Mouse))	BDBM50346975 (CHEMBL1795889) Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1ccc(N)nc1 Show InChI InChI=1S/C37H34N6O2/c1-23-19-30(10-11-31(23)24-3-5-25(6-4-24)37(45)41-29-15-17-42(2)18-16-29)43-35(44)14-9-28-22-39-33-12-7-26(20-32(33)36(28)43)27-8-13-34(38)40-21-27/h3-14,19-22,29H,15-18H2,1-2H3,(H2,38,40)(H,41,45)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
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