BDBM50347418 CHEMBL1801548

SMILES: Cc1nc2ccc(CN(CC#C)c3ccc(cc3)C(=O)NCc3ccc(F)c(F)c3F)cc2c(=O)n1C

InChI Key: InChIKey=PAQPJDBKUJZNDL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50347418   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50347418 (CHEMBL1801548) Show SMILES Cc1nc2ccc(CN(CC#C)c3ccc(cc3)C(=O)NCc3ccc(F)c(F)c3F)cc2c(=O)n1C Show InChI InChI=1S/C28H23F3N4O2/c1-4-13-35(16-18-5-12-24-22(14-18)28(37)34(3)17(2)33-24)21-9-6-19(7-10-21)27(36)32-15-20-8-11-23(29)26(31)25(20)30/h1,5-12,14H,13,15-16H2,2-3H3,(H,32,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
Myrexis, Inc. Curated by ChEMBL					Assay Description Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotide				J Med Chem 53: 8734-46 (2010) Article DOI: 10.1021/jm101145b BindingDB Entry DOI: 10.7270/Q26H4HSP
					More data for this Ligand-Target Pair