BDBM50347440 CHEMBL1801871

SMILES: Cc1nc2CCN(Cc2c(=O)[nH]1)C(=O)c1ccc(cc1)C(=O)NCc1cccnc1

InChI Key: InChIKey=ABHOCMMLPGQSBW-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50347440   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50347440 (CHEMBL1801871) Show SMILES Cc1nc2CCN(Cc2c(=O)[nH]1)C(=O)c1ccc(cc1)C(=O)NCc1cccnc1 Show InChI InChI=1S/C22H21N5O3/c1-14-25-19-8-10-27(13-18(19)21(29)26-14)22(30)17-6-4-16(5-7-17)20(28)24-12-15-3-2-9-23-11-15/h2-7,9,11H,8,10,12-13H2,1H3,(H,24,28)(H,25,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Myrexis, Inc. Curated by ChEMBL					Assay Description Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotide				J Med Chem 53: 8734-46 (2010) Article DOI: 10.1021/jm101145b BindingDB Entry DOI: 10.7270/Q26H4HSP
					More data for this Ligand-Target Pair