Found 4 hits for monomerid = 50349097 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dual specificity protein kinase TTK
(Homo sapiens (Human)) | BDBM50349097
(CHEMBL1808336)Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3OC)nc-21 Show InChI InChI=1S/C28H30N6O2/c1-5-17-10-9-11-18(6-2)23(17)31-27(35)25-20-15-14-19-16-29-28(32-24(19)26(20)34(3)33-25)30-21-12-7-8-13-22(21)36-4/h7-13,16H,5-6,14-15H2,1-4H3,(H,31,35)(H,29,30,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 525 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description
Inhibition of MPS1 assessed as [33P]-gamma-ATP incorporation into substrate P38-betatide by gamma counting |
Bioorg Med Chem Lett 21: 4507-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.122
BindingDB Entry DOI: 10.7270/Q2R211RS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50349097
(CHEMBL1808336)Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3OC)nc-21 Show InChI InChI=1S/C28H30N6O2/c1-5-17-10-9-11-18(6-2)23(17)31-27(35)25-20-15-14-19-16-29-28(32-24(19)26(20)34(3)33-25)30-21-12-7-8-13-22(21)36-4/h7-13,16H,5-6,14-15H2,1-4H3,(H,31,35)(H,29,30,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description
Inhibition of PLK1 assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting |
Bioorg Med Chem Lett 21: 4507-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.122
BindingDB Entry DOI: 10.7270/Q2R211RS |
More data for this
Ligand-Target Pair | |
Cyclin-Dependent Kinase 2 (CDK2)
(Homo sapiens (Human)) | BDBM50349097
(CHEMBL1808336)Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3OC)nc-21 Show InChI InChI=1S/C28H30N6O2/c1-5-17-10-9-11-18(6-2)23(17)31-27(35)25-20-15-14-19-16-29-28(32-24(19)26(20)34(3)33-25)30-21-12-7-8-13-22(21)36-4/h7-13,16H,5-6,14-15H2,1-4H3,(H,31,35)(H,29,30,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description
Inhibition of CDK2/Cyclin A assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting |
Bioorg Med Chem Lett 21: 4507-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.122
BindingDB Entry DOI: 10.7270/Q2R211RS |
More data for this
Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50349097
(CHEMBL1808336)Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3OC)nc-21 Show InChI InChI=1S/C28H30N6O2/c1-5-17-10-9-11-18(6-2)23(17)31-27(35)25-20-15-14-19-16-29-28(32-24(19)26(20)34(3)33-25)30-21-12-7-8-13-22(21)36-4/h7-13,16H,5-6,14-15H2,1-4H3,(H,31,35)(H,29,30,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description
Inhibition of Aur-A assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting |
Bioorg Med Chem Lett 21: 4507-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.122
BindingDB Entry DOI: 10.7270/Q2R211RS |
More data for this
Ligand-Target Pair | |
Search and Browse
