BDBM50349469 CHEMBL1808589

SMILES: Cc1c(CNCCO)cncc1-c1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1

InChI Key: InChIKey=QJZIBKKHTMXJGL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50349469   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349469 (CHEMBL1808589) Show SMILES Cc1c(CNCCO)cncc1-c1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1 Show InChI InChI=1S/C23H22N6O/c1-14-16(11-24-8-9-30)12-25-13-18(14)15-6-7-19-17(10-15)22(29-28-19)23-26-20-4-2-3-5-21(20)27-23/h2-7,10,12-13,24,30H,8-9,11H2,1H3,(H,26,27)(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair