BDBM50351370 CHEMBL1819060

SMILES: CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1ccc(OC)cc1C

InChI Key: InChIKey=CFUUSJFFQOJXBU-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50351370   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50351370 (CHEMBL1819060) Show SMILES CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1ccc(OC)cc1C |(-2.08,4.74,;-3.43,3.99,;-3.46,2.45,;-2.14,1.66,;-.79,2.41,;-4.8,1.71,;-4.83,.17,;-6.18,-.57,;-7.64,-.07,;-8.57,-1.3,;-7.69,-2.56,;-6.21,-2.12,;-4.89,-2.91,;-3.53,-2.16,;-2.08,-2.65,;-1.16,-1.42,;.38,-1.43,;-2.05,-.16,;-3.51,-.62,;-1.62,-4.12,;-2.66,-5.25,;-2.21,-6.72,;-.7,-7.05,;-.24,-8.52,;-1.29,-9.66,;.34,-5.91,;-.12,-4.45,;.92,-3.31,)| Show InChI InChI=1S/C23H30N4O/c1-6-16(7-2)24-22-19-9-8-10-20(19)25-23-21(15(4)26-27(22)23)18-12-11-17(28-5)13-14(18)3/h11-13,16,24H,6-10H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP productio...				Bioorg Med Chem 19: 5432-45 (2011) Article DOI: 10.1016/j.bmc.2011.07.055 BindingDB Entry DOI: 10.7270/Q2Z038JX
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50351370 (CHEMBL1819060) Show SMILES CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1ccc(OC)cc1C |(-2.08,4.74,;-3.43,3.99,;-3.46,2.45,;-2.14,1.66,;-.79,2.41,;-4.8,1.71,;-4.83,.17,;-6.18,-.57,;-7.64,-.07,;-8.57,-1.3,;-7.69,-2.56,;-6.21,-2.12,;-4.89,-2.91,;-3.53,-2.16,;-2.08,-2.65,;-1.16,-1.42,;.38,-1.43,;-2.05,-.16,;-3.51,-.62,;-1.62,-4.12,;-2.66,-5.25,;-2.21,-6.72,;-.7,-7.05,;-.24,-8.52,;-1.29,-9.66,;.34,-5.91,;-.12,-4.45,;.92,-3.31,)| Show InChI InChI=1S/C23H30N4O/c1-6-16(7-2)24-22-19-9-8-10-20(19)25-23-21(15(4)26-27(22)23)18-12-11-17(28-5)13-14(18)3/h11-13,16,24H,6-10H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells after 2 hrs by gamma counting				Bioorg Med Chem 19: 5432-45 (2011) Article DOI: 10.1016/j.bmc.2011.07.055 BindingDB Entry DOI: 10.7270/Q2Z038JX
					More data for this Ligand-Target Pair