BDBM50351374 CHEMBL1819064

SMILES: CCC(CC)Nc1c2COCc2nc2c(c(C)nn12)-c1ccc(OC)cc1C

InChI Key: InChIKey=LLTPBNKXSYWJPS-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50351374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50351374 (CHEMBL1819064) Show SMILES CCC(CC)Nc1c2COCc2nc2c(c(C)nn12)-c1ccc(OC)cc1C |(15.25,-13.3,;13.9,-14.05,;13.87,-15.59,;15.19,-16.38,;16.54,-15.64,;12.53,-16.33,;12.5,-17.87,;11.14,-18.62,;9.69,-18.11,;8.76,-19.35,;9.64,-20.61,;11.12,-20.16,;12.44,-20.96,;13.8,-20.2,;15.25,-20.69,;16.17,-19.46,;17.71,-19.48,;15.28,-18.21,;13.81,-18.66,;15.71,-22.16,;14.66,-23.29,;15.12,-24.76,;16.63,-25.1,;17.09,-26.57,;16.04,-27.7,;17.67,-23.96,;17.21,-22.49,;18.25,-21.36,)| Show InChI InChI=1S/C22H28N4O2/c1-6-15(7-2)23-21-18-11-28-12-19(18)24-22-20(14(4)25-26(21)22)17-9-8-16(27-5)10-13(17)3/h8-10,15,23H,6-7,11-12H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	75	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP productio...				Bioorg Med Chem 19: 5432-45 (2011) Article DOI: 10.1016/j.bmc.2011.07.055 BindingDB Entry DOI: 10.7270/Q2Z038JX
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50351374 (CHEMBL1819064) Show SMILES CCC(CC)Nc1c2COCc2nc2c(c(C)nn12)-c1ccc(OC)cc1C |(15.25,-13.3,;13.9,-14.05,;13.87,-15.59,;15.19,-16.38,;16.54,-15.64,;12.53,-16.33,;12.5,-17.87,;11.14,-18.62,;9.69,-18.11,;8.76,-19.35,;9.64,-20.61,;11.12,-20.16,;12.44,-20.96,;13.8,-20.2,;15.25,-20.69,;16.17,-19.46,;17.71,-19.48,;15.28,-18.21,;13.81,-18.66,;15.71,-22.16,;14.66,-23.29,;15.12,-24.76,;16.63,-25.1,;17.09,-26.57,;16.04,-27.7,;17.67,-23.96,;17.21,-22.49,;18.25,-21.36,)| Show InChI InChI=1S/C22H28N4O2/c1-6-15(7-2)23-21-18-11-28-12-19(18)24-22-20(14(4)25-26(21)22)17-9-8-16(27-5)10-13(17)3/h8-10,15,23H,6-7,11-12H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells after 2 hrs by gamma counting				Bioorg Med Chem 19: 5432-45 (2011) Article DOI: 10.1016/j.bmc.2011.07.055 BindingDB Entry DOI: 10.7270/Q2Z038JX
					More data for this Ligand-Target Pair