BDBM50351892 CHEMBL1821791

SMILES: COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1

InChI Key: InChIKey=RVTQRSDLGBOKCF-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50351892   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (Human))	BDBM50351892 (CHEMBL1821791) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1 Show InChI InChI=1S/C19H19NO3/c1-21-15-6-4-13(5-7-15)10-17-16-12-19(23-3)18(22-2)11-14(16)8-9-20-17/h4-9,11-12H,10H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351892 (CHEMBL1821791) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1 Show InChI InChI=1S/C19H19NO3/c1-21-15-6-4-13(5-7-15)10-17-16-12-19(23-3)18(22-2)11-14(16)8-9-20-17/h4-9,11-12H,10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48.8	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (PDE3) (Homo sapiens (Human))	BDBM50351892 (CHEMBL1821791) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1 Show InChI InChI=1S/C19H19NO3/c1-21-15-6-4-13(5-7-15)10-17-16-12-19(23-3)18(22-2)11-14(16)8-9-20-17/h4-9,11-12H,10H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
					More data for this Ligand-Target Pair