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BDBM50352044 CHEMBL1824007

SMILES: FC(F)(F)c1ccc(nc1)-c1ccc(Cl)c(c1)C(=O)NCCc1ccccc1Cl

InChI Key: InChIKey=OBKVOVQRLZZJGU-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50352044   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))		BDBM50352044
PNG
(CHEMBL1824007)
Show SMILES FC(F)(F)c1ccc(nc1)-c1ccc(Cl)c(c1)C(=O)NCCc1ccccc1Cl
Show InChI InChI=1S/C21H15Cl2F3N2O/c22-17-4-2-1-3-13(17)9-10-27-20(29)16-11-14(5-7-18(16)23)19-8-6-15(12-28-19)21(24,25)26/h1-8,11-12H,9-10H2,(H,27,29)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
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AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.60E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...

Bioorg Med Chem Lett 21: 5475-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.117
BindingDB Entry DOI: 10.7270/Q2PC32RF
More data for this
Ligand-Target Pair