BDBM50353333 CHEMBL1831053

SMILES: CN1C(c2ccc(C)o2)c2n(c(-c3ccccc3)c3c2n(C)c(=O)n(C)c3=O)-c2ccccc12

InChI Key: InChIKey=JIDDZVVFHRQWKU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50353333   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50353333 (CHEMBL1831053) Show SMILES CN1C(c2ccc(C)o2)c2n(c(-c3ccccc3)c3c2n(C)c(=O)n(C)c3=O)-c2ccccc12 Show InChI InChI=1S/C27H24N4O3/c1-16-14-15-20(34-16)23-25-24-21(26(32)30(4)27(33)29(24)3)22(17-10-6-5-7-11-17)31(25)19-13-9-8-12-18(19)28(23)2/h5-15,23H,1-4H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...				J Med Chem 54: 5468-77 (2011) Article DOI: 10.1021/jm200505e BindingDB Entry DOI: 10.7270/Q2280809
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