BDBM50354010 CHEMBL1828895

SMILES: CCCN(CCC)c1c(OC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12

InChI Key: InChIKey=SRVOXYMGPZGQQZ-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50354010   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50354010 (CHEMBL1828895) Show SMILES CCCN(CCC)c1c(OC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 Show InChI InChI=1S/C20H26ClN5O2/c1-5-11-25(12-6-2)20-18(28-4)19(24-17-9-10-22-26(17)20)23-16-8-7-14(27-3)13-15(16)21/h7-10,13H,5-6,11-12H2,1-4H3,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	883	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...				Bioorg Med Chem 19: 5955-66 (2011) Article DOI: 10.1016/j.bmc.2011.08.055 BindingDB Entry DOI: 10.7270/Q24X5862
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50354010 (CHEMBL1828895) Show SMILES CCCN(CCC)c1c(OC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 Show InChI InChI=1S/C20H26ClN5O2/c1-5-11-25(12-6-2)20-18(28-4)19(24-17-9-10-22-26(17)20)23-16-8-7-14(27-3)13-15(16)21/h7-10,13H,5-6,11-12H2,1-4H3,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counting				Bioorg Med Chem 19: 5955-66 (2011) Article DOI: 10.1016/j.bmc.2011.08.055 BindingDB Entry DOI: 10.7270/Q24X5862
					More data for this Ligand-Target Pair