Found 11 hits for monomerid = 50354492 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50354492
(CHEMBL260994)Show SMILES Clc1ccc(cc1)N1CCN(CCCCC2C(=O)Nc3ccccc23)CC1 |w:15.15| Show InChI InChI=1S/C22H26ClN3O/c23-17-8-10-18(11-9-17)26-15-13-25(14-16-26)12-4-3-6-20-19-5-1-2-7-21(19)24-22(20)27/h1-2,5,7-11,20H,3-4,6,12-16H2,(H,24,27) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells |
J Med Chem 51: 2522-32 (2008)
Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50354492
(CHEMBL260994)Show SMILES Clc1ccc(cc1)N1CCN(CCCCC2C(=O)Nc3ccccc23)CC1 |w:15.15| Show InChI InChI=1S/C22H26ClN3O/c23-17-8-10-18(11-9-17)26-15-13-25(14-16-26)12-4-3-6-20-19-5-1-2-7-21(19)24-22(20)27/h1-2,5,7-11,20H,3-4,6,12-16H2,(H,24,27) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc.
Curated by ChEMBL
| Assay Description Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry |
J Med Chem 54: 6657-69 (2011)
Article DOI: 10.1021/jm200547z BindingDB Entry DOI: 10.7270/Q25Q4WGZ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50354492
(CHEMBL260994)Show SMILES Clc1ccc(cc1)N1CCN(CCCCC2C(=O)Nc3ccccc23)CC1 |w:15.15| Show InChI InChI=1S/C22H26ClN3O/c23-17-8-10-18(11-9-17)26-15-13-25(14-16-26)12-4-3-6-20-19-5-1-2-7-21(19)24-22(20)27/h1-2,5,7-11,20H,3-4,6,12-16H2,(H,24,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 17.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc
Curated by ChEMBL
| Assay Description Inhibition of 5HT2A receptor |
J Med Chem 51: 2522-32 (2008)
Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50354492
(CHEMBL260994)Show SMILES Clc1ccc(cc1)N1CCN(CCCCC2C(=O)Nc3ccccc23)CC1 |w:15.15| Show InChI InChI=1S/C22H26ClN3O/c23-17-8-10-18(11-9-17)26-15-13-25(14-16-26)12-4-3-6-20-19-5-1-2-7-21(19)24-22(20)27/h1-2,5,7-11,20H,3-4,6,12-16H2,(H,24,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc.
Curated by ChEMBL
| Assay Description Binding affinity to 5-HT2A receptor by radioligand binding assay |
J Med Chem 54: 6657-69 (2011)
Article DOI: 10.1021/jm200547z BindingDB Entry DOI: 10.7270/Q25Q4WGZ |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50354492
(CHEMBL260994)Show SMILES Clc1ccc(cc1)N1CCN(CCCCC2C(=O)Nc3ccccc23)CC1 |w:15.15| Show InChI InChI=1S/C22H26ClN3O/c23-17-8-10-18(11-9-17)26-15-13-25(14-16-26)12-4-3-6-20-19-5-1-2-7-21(19)24-22(20)27/h1-2,5,7-11,20H,3-4,6,12-16H2,(H,24,27) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 42 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc
Curated by ChEMBL
| Assay Description Inhibition of adrenergic alpha-1 receptor |
J Med Chem 51: 2522-32 (2008)
Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50354492
(CHEMBL260994)Show SMILES Clc1ccc(cc1)N1CCN(CCCCC2C(=O)Nc3ccccc23)CC1 |w:15.15| Show InChI InChI=1S/C22H26ClN3O/c23-17-8-10-18(11-9-17)26-15-13-25(14-16-26)12-4-3-6-20-19-5-1-2-7-21(19)24-22(20)27/h1-2,5,7-11,20H,3-4,6,12-16H2,(H,24,27) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 580 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc
Curated by ChEMBL
| Assay Description Inhibition of 5HT6 receptor |
J Med Chem 51: 2522-32 (2008)
Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50354492
(CHEMBL260994)Show SMILES Clc1ccc(cc1)N1CCN(CCCCC2C(=O)Nc3ccccc23)CC1 |w:15.15| Show InChI InChI=1S/C22H26ClN3O/c23-17-8-10-18(11-9-17)26-15-13-25(14-16-26)12-4-3-6-20-19-5-1-2-7-21(19)24-22(20)27/h1-2,5,7-11,20H,3-4,6,12-16H2,(H,24,27) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc
Curated by ChEMBL
| Assay Description Inhibition of 5HT2C receptor |
J Med Chem 51: 2522-32 (2008)
Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50354492
(CHEMBL260994)Show SMILES Clc1ccc(cc1)N1CCN(CCCCC2C(=O)Nc3ccccc23)CC1 |w:15.15| Show InChI InChI=1S/C22H26ClN3O/c23-17-8-10-18(11-9-17)26-15-13-25(14-16-26)12-4-3-6-20-19-5-1-2-7-21(19)24-22(20)27/h1-2,5,7-11,20H,3-4,6,12-16H2,(H,24,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 960 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc
Curated by ChEMBL
| Assay Description Inhibition of dopamine D2 receptor |
J Med Chem 51: 2522-32 (2008)
Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50354492
(CHEMBL260994)Show SMILES Clc1ccc(cc1)N1CCN(CCCCC2C(=O)Nc3ccccc23)CC1 |w:15.15| Show InChI InChI=1S/C22H26ClN3O/c23-17-8-10-18(11-9-17)26-15-13-25(14-16-26)12-4-3-6-20-19-5-1-2-7-21(19)24-22(20)27/h1-2,5,7-11,20H,3-4,6,12-16H2,(H,24,27) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc.
Curated by ChEMBL
| Assay Description Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat frontal cortex membrane after 45 mins by scintillation counting |
J Med Chem 54: 6657-69 (2011)
Article DOI: 10.1021/jm200547z BindingDB Entry DOI: 10.7270/Q25Q4WGZ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50354492
(CHEMBL260994)Show SMILES Clc1ccc(cc1)N1CCN(CCCCC2C(=O)Nc3ccccc23)CC1 |w:15.15| Show InChI InChI=1S/C22H26ClN3O/c23-17-8-10-18(11-9-17)26-15-13-25(14-16-26)12-4-3-6-20-19-5-1-2-7-21(19)24-22(20)27/h1-2,5,7-11,20H,3-4,6,12-16H2,(H,24,27) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc
Curated by ChEMBL
| Assay Description Inhibition of 5HT1A receptor in rat frontal cortex membrane |
J Med Chem 51: 2522-32 (2008)
Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0 |
More data for this Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50354492
(CHEMBL260994)Show SMILES Clc1ccc(cc1)N1CCN(CCCCC2C(=O)Nc3ccccc23)CC1 |w:15.15| Show InChI InChI=1S/C22H26ClN3O/c23-17-8-10-18(11-9-17)26-15-13-25(14-16-26)12-4-3-6-20-19-5-1-2-7-21(19)24-22(20)27/h1-2,5,7-11,20H,3-4,6,12-16H2,(H,24,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc
Curated by ChEMBL
| Assay Description Inhibition of dopamine D1 receptor |
J Med Chem 51: 2522-32 (2008)
Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0 |
More data for this Ligand-Target Pair | |