BindingDB PrimarySearch

BDBM50354493 CHEMBL409662

SMILES: CCC1(CCCCN2CCN(CC2)c2ccc(Cl)cc2)C(=O)Nc2cc(F)ccc12

InChI Key: InChIKey=QFHWIGIQQPTXBG-UHFFFAOYSA-N

Data: 13 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50354493
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50354493 (CHEMBL409662) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Normandie Univ Curated by ChEMBL					Assay Description Antagonist activity at 5-HT7 receptor (unknown origin)				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111705
Normandie Univ Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50354493 (CHEMBL409662) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
EGIS Pharmaceuticals Plc. Curated by ChEMBL					Assay Description Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry				J Med Chem 54: 6657-69 (2011) Article DOI: 10.1021/jm200547z BindingDB Entry DOI: 10.7270/Q25Q4WGZ
EGIS Pharmaceuticals Plc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50354493 (CHEMBL409662) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
EGIS Pharmaceuticals Plc Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells				J Med Chem 51: 2522-32 (2008) Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0
EGIS Pharmaceuticals Plc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50354493 (CHEMBL409662) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
EGIS Pharmaceuticals Plc. Curated by ChEMBL					Assay Description Binding affinity to 5-HT2A receptor by radioligand binding assay				J Med Chem 54: 6657-69 (2011) Article DOI: 10.1021/jm200547z BindingDB Entry DOI: 10.7270/Q25Q4WGZ
EGIS Pharmaceuticals Plc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50354493 (CHEMBL409662) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
EGIS Pharmaceuticals Plc Curated by ChEMBL					Assay Description Inhibition of 5HT2A receptor				J Med Chem 51: 2522-32 (2008) Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0
EGIS Pharmaceuticals Plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50354493 (CHEMBL409662) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	71.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
EGIS Pharmaceuticals Plc Curated by ChEMBL					Assay Description Inhibition of adrenergic alpha-1 receptor				J Med Chem 51: 2522-32 (2008) Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0
EGIS Pharmaceuticals Plc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50354493 (CHEMBL409662) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	187	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
EGIS Pharmaceuticals Plc Curated by ChEMBL					Assay Description Inhibition of 5HT6 receptor				J Med Chem 51: 2522-32 (2008) Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0
EGIS Pharmaceuticals Plc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50354493 (CHEMBL409662) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	358	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
EGIS Pharmaceuticals Plc Curated by ChEMBL					Assay Description Inhibition of 5HT2C receptor				J Med Chem 51: 2522-32 (2008) Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0
EGIS Pharmaceuticals Plc Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50354493 (CHEMBL409662) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
EGIS Pharmaceuticals Plc Curated by ChEMBL					Assay Description Inhibition of dopamine D2 receptor				J Med Chem 51: 2522-32 (2008) Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0
EGIS Pharmaceuticals Plc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50354493 (CHEMBL409662) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.61E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
EGIS Pharmaceuticals Plc Curated by ChEMBL					Assay Description Inhibition of 5HT1A receptor in rat frontal cortex membrane				J Med Chem 51: 2522-32 (2008) Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0
EGIS Pharmaceuticals Plc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50354493 (CHEMBL409662) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.61E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
EGIS Pharmaceuticals Plc. Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat frontal cortex membrane after 45 mins by scintillation counting				J Med Chem 54: 6657-69 (2011) Article DOI: 10.1021/jm200547z BindingDB Entry DOI: 10.7270/Q25Q4WGZ
EGIS Pharmaceuticals Plc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50354493 (CHEMBL409662) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.61E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Normandie Univ Curated by ChEMBL					Assay Description Antagonist activity at 5-HT1A receptor (unknown origin)				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111705
Normandie Univ Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50354493 (CHEMBL409662) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.36E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
EGIS Pharmaceuticals Plc Curated by ChEMBL					Assay Description Inhibition of dopamine D1 receptor				J Med Chem 51: 2522-32 (2008) Article DOI: 10.1021/jm070279v BindingDB Entry DOI: 10.7270/Q2QF8TQ0
EGIS Pharmaceuticals Plc Curated by ChEMBL					More data for this Ligand-Target Pair