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BDBM50354855 CHEMBL1834536

SMILES: C[C@]12C[C@H](O)[C@@]3(F)[C@@H](C[C@H](F)C4=CC(=O)C=C[C@]34C)[C@@H]1C[C@H]1O[C@H](O[C@@]21C(=O)CO)c1ccc(CN2CCOCC2)cc1

InChI Key: InChIKey=IBZXUDZFZNREME-DFBFCLLYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50354855   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50354855
PNG
(CHEMBL1834536)
Show SMILES C[C@]12C[C@H](O)[C@@]3(F)[C@@H](C[C@H](F)C4=CC(=O)C=C[C@]34C)[C@@H]1C[C@H]1O[C@H](O[C@@]21C(=O)CO)c1ccc(CN2CCOCC2)cc1 |r,c:15,t:11|
Show InChI InChI=1S/C33H39F2NO7/c1-30-8-7-21(38)13-24(30)25(34)14-23-22-15-28-33(27(40)18-37,31(22,2)16-26(39)32(23,30)35)43-29(42-28)20-5-3-19(4-6-20)17-36-9-11-41-12-10-36/h3-8,13,22-23,25-26,28-29,37,39H,9-12,14-18H2,1-2H3/t22-,23-,25-,26-,28+,29+,30-,31-,32-,33+/m0/s1
PDB

KEGG

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Similars
Article
PubMed
n/an/an/an/a 0.710n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GR in human SW1353 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 5826-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.106
BindingDB Entry DOI: 10.7270/Q22V2GH4
More data for this
Ligand-Target Pair