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SMILES: COc1ccc(c(C)c1)-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc12

InChI Key: InChIKey=UZPJXDUEOHPKCO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50354968   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354968
PNG
(CHEMBL1836933)
Show SMILES COc1ccc(c(C)c1)-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc12 |(20.29,-8.23,;21.04,-6.89,;20.24,-5.57,;18.7,-5.59,;17.91,-4.27,;18.66,-2.93,;20.2,-2.9,;20.94,-1.55,;20.99,-4.21,;17.87,-1.61,;18.78,-.36,;20.32,-.36,;17.87,.9,;16.4,.42,;15.06,1.18,;15.06,2.72,;13.72,3.49,;13.72,5.03,;14.48,6.35,;12.94,6.35,;12.39,2.71,;10.85,2.71,;11.62,1.38,;13.73,.41,;13.73,-1.13,;12.4,-1.9,;15.07,-1.9,;16.4,-1.13,)|
Show InChI InChI=1S/C22H27N5O/c1-12-11-17(28-4)9-10-18(12)27-14(3)25-20-21(23-13(2)24-22(20)27)26-19(15-5-6-15)16-7-8-16/h9-11,15-16,19H,5-8H2,1-4H3,(H,23,24,26)
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Article
PubMed
 14n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation

Bioorg Med Chem Lett 21: 6108-11 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.040
BindingDB Entry DOI: 10.7270/Q2F19046
More data for this
Ligand-Target Pair