BDBM50354972 CHEMBL1836937

SMILES: COc1ccc(cc1)-n1c(nc2c(NC(C3CC3)C3CC3)nc(C)nc12)C1CCCO1

InChI Key: InChIKey=ZGQZTHWLDSRLAV-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50354972   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50354972 (CHEMBL1836937) Show SMILES COc1ccc(cc1)-n1c(nc2c(NC(C3CC3)C3CC3)nc(C)nc12)C1CCCO1 Show InChI InChI=1S/C24H29N5O2/c1-14-25-22(27-20(15-5-6-15)16-7-8-16)21-24(26-14)29(17-9-11-18(30-2)12-10-17)23(28-21)19-4-3-13-31-19/h9-12,15-16,19-20H,3-8,13H2,1-2H3,(H,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	867	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation				Bioorg Med Chem Lett 21: 6108-11 (2011) Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046
					More data for this Ligand-Target Pair