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BDBM50354973 CHEMBL1836938

SMILES: COc1ccc(cc1)-n1c(nc2c(NC(C3CC3)C3CC3)nc(C)nc12)C1CC(F)(F)C1

InChI Key: InChIKey=NTHFTLKKUFFWIM-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50354973   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50354973
PNG
(CHEMBL1836938)
Show SMILES COc1ccc(cc1)-n1c(nc2c(NC(C3CC3)C3CC3)nc(C)nc12)C1CC(F)(F)C1
Show InChI InChI=1S/C24H27F2N5O/c1-13-27-21(29-19(14-3-4-14)15-5-6-15)20-23(28-13)31(17-7-9-18(32-2)10-8-17)22(30-20)16-11-24(25,26)12-16/h7-10,14-16,19H,3-6,11-12H2,1-2H3,(H,27,28,29)
PDB
MMDB

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PC cid
PC sid
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Similars

Article
PubMed
261n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation


Bioorg Med Chem Lett 21: 6108-11 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.040
BindingDB Entry DOI: 10.7270/Q2F19046
More data for this
Ligand-Target Pair