BDBM50355147 CHEMBL1834556

SMILES: Nc1ncnc2OC[C@@H](Oc12)c1ccc(cc1)[C@H]1CC[C@H](CC#N)CC1

InChI Key: InChIKey=ANLQIPIJDXZXNV-CKEIUWERSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50355147   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50355147 (CHEMBL1834556) Show SMILES Nc1ncnc2OC[C@@H](Oc12)c1ccc(cc1)[C@H]1CC[C@H](CC#N)CC1 |r,wU:8.12,17.19,wD:20.23,(-8.65,-22.04,;-8.64,-23.58,;-9.97,-24.35,;-9.98,-25.9,;-8.64,-26.67,;-7.3,-25.9,;-5.96,-26.67,;-4.62,-25.88,;-4.62,-24.34,;-5.97,-23.56,;-7.31,-24.35,;-3.3,-23.57,;-1.96,-24.33,;-.63,-23.54,;-.65,-22,;-2,-21.25,;-3.32,-22.04,;.67,-21.22,;.65,-19.68,;1.98,-18.9,;3.32,-19.66,;4.65,-18.88,;4.63,-17.34,;4.61,-15.8,;3.33,-21.2,;2.01,-21.98,)| Show InChI InChI=1S/C20H22N4O2/c21-10-9-13-1-3-14(4-2-13)15-5-7-16(8-6-15)17-11-25-20-18(26-17)19(22)23-12-24-20/h5-8,12-14,17H,1-4,9,11H2,(H2,22,23,24)/t13-,14-,17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	175	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human DGAT-1-mediated triglyceride synthesis in the HT-29 cells by whole cell assay				Bioorg Med Chem Lett 21: 6122-5 (2011) Article DOI: 10.1016/j.bmcl.2011.08.028 BindingDB Entry DOI: 10.7270/Q2MK6D9B
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50355147 (CHEMBL1834556) Show SMILES Nc1ncnc2OC[C@@H](Oc12)c1ccc(cc1)[C@H]1CC[C@H](CC#N)CC1 |r,wU:8.12,17.19,wD:20.23,(-8.65,-22.04,;-8.64,-23.58,;-9.97,-24.35,;-9.98,-25.9,;-8.64,-26.67,;-7.3,-25.9,;-5.96,-26.67,;-4.62,-25.88,;-4.62,-24.34,;-5.97,-23.56,;-7.31,-24.35,;-3.3,-23.57,;-1.96,-24.33,;-.63,-23.54,;-.65,-22,;-2,-21.25,;-3.32,-22.04,;.67,-21.22,;.65,-19.68,;1.98,-18.9,;3.32,-19.66,;4.65,-18.88,;4.63,-17.34,;4.61,-15.8,;3.33,-21.2,;2.01,-21.98,)| Show InChI InChI=1S/C20H22N4O2/c21-10-9-13-1-3-14(4-2-13)15-5-7-16(8-6-15)17-11-25-20-18(26-17)19(22)23-12-24-20/h5-8,12-14,17H,1-4,9,11H2,(H2,22,23,24)/t13-,14-,17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	249	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human DGAT1				Bioorg Med Chem Lett 21: 6122-5 (2011) Article DOI: 10.1016/j.bmcl.2011.08.028 BindingDB Entry DOI: 10.7270/Q2MK6D9B
					More data for this Ligand-Target Pair