BDBM50357594 CHEMBL1915445
SMILES: Oc1ccc(Nc2nc3c(cccc3c3cnccc23)-c2nnc[nH]2)c(Cl)c1
InChI Key: InChIKey=RRCCIDQPUXDUMY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM50357594 (CHEMBL1915445) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 30 uM [ATP] | Bioorg Med Chem Lett 21: 6687-92 (2011) Article DOI: 10.1016/j.bmcl.2011.09.059 BindingDB Entry DOI: 10.7270/Q2PR7WD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human)) | BDBM50357594 (CHEMBL1915445) | PDB MMDB KEGG B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of PIM2 by millipore assay in the presence of 15 uM [ATP] | Bioorg Med Chem Lett 21: 6687-92 (2011) Article DOI: 10.1016/j.bmcl.2011.09.059 BindingDB Entry DOI: 10.7270/Q2PR7WD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human)) | BDBM50357594 (CHEMBL1915445) | KEGG GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 875 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of PIM3 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 155 uM [ATP] | Bioorg Med Chem Lett 21: 6687-92 (2011) Article DOI: 10.1016/j.bmcl.2011.09.059 BindingDB Entry DOI: 10.7270/Q2PR7WD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM50357594 (CHEMBL1915445) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of PIM1 using KKRNRTLTV as substrate by millipore assay in the presence of 90 uM [ATP] | Bioorg Med Chem Lett 21: 6687-92 (2011) Article DOI: 10.1016/j.bmcl.2011.09.059 BindingDB Entry DOI: 10.7270/Q2PR7WD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl2-antagonist of cell death (BAD) (Homo sapiens (Human)) | BDBM50357594 (CHEMBL1915445) | NCI pathway Reactome pathway KEGG GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 90 | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA | Bioorg Med Chem Lett 21: 6687-92 (2011) Article DOI: 10.1016/j.bmcl.2011.09.059 BindingDB Entry DOI: 10.7270/Q2PR7WD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50357594 (CHEMBL1915445) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of FLT3 phosphorylation at Tyr591 in human MV-4-11 cells assessed as phospho-FLT3 level after 4 hrs by ELISA | Bioorg Med Chem Lett 21: 6687-92 (2011) Article DOI: 10.1016/j.bmcl.2011.09.059 BindingDB Entry DOI: 10.7270/Q2PR7WD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human)) | BDBM50357594 (CHEMBL1915445) | PDB MMDB KEGG B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP] | Bioorg Med Chem Lett 21: 6687-92 (2011) Article DOI: 10.1016/j.bmcl.2011.09.059 BindingDB Entry DOI: 10.7270/Q2PR7WD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50357594 (CHEMBL1915445) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of FLT3 using EAIYAAPFAKKK as substrate by radiometric assay in the presence of 200 uM [ATP] | Bioorg Med Chem Lett 21: 6687-92 (2011) Article DOI: 10.1016/j.bmcl.2011.09.059 BindingDB Entry DOI: 10.7270/Q2PR7WD6 | |||||||||||
More data for this Ligand-Target Pair |