BDBM50357648 CHEMBL1914716

SMILES: Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncncc2c1

InChI Key: InChIKey=FDCNRCBAXUDBRG-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50357648   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50357648 (CHEMBL1914716) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncncc2c1 Show InChI InChI=1S/C19H12ClFN4O2S/c20-19-18(25-28(26,27)16-4-2-15(21)3-5-16)8-13(10-23-19)12-1-6-17-14(7-12)9-22-11-24-17/h1-11,25H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser 473 in human U87MG cells				J Med Chem 54: 4735-51 (2011) Article DOI: 10.1021/jm200386s BindingDB Entry DOI: 10.7270/Q2FB53C5
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50357648 (CHEMBL1914716) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncncc2c1 Show InChI InChI=1S/C19H12ClFN4O2S/c20-19-18(25-28(26,27)16-4-2-15(21)3-5-16)8-13(10-23-19)12-1-6-17-14(7-12)9-22-11-24-17/h1-11,25H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser 473 in human U87MG cells				J Med Chem 54: 4735-51 (2011) Article DOI: 10.1021/jm200386s BindingDB Entry DOI: 10.7270/Q2FB53C5
					More data for this Ligand-Target Pair