BDBM50357849 CHEMBL1916108

SMILES: Cc1nc(-c2ccncc2C)n2c1c(C)nc1ccc(cc21)C(F)(F)F

InChI Key: InChIKey=HZQYJFKDDWTULI-UHFFFAOYSA-N

Data: 11 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50357849   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50357849 (CHEMBL1916108) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1ccc(cc21)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-9-23-7-6-14(10)18-25-12(3)17-11(2)24-15-5-4-13(19(20,21)22)8-16(15)26(17)18/h4-9H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE5A using [3H]cGMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Homo sapiens (Human))	BDBM50357849 (CHEMBL1916108) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1ccc(cc21)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-9-23-7-6-14(10)18-25-12(3)17-11(2)24-15-5-4-13(19(20,21)22)8-16(15)26(17)18/h4-9H,1-3H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE11A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50357849 (CHEMBL1916108) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1ccc(cc21)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-9-23-7-6-14(10)18-25-12(3)17-11(2)24-15-5-4-13(19(20,21)22)8-16(15)26(17)18/h4-9H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Homo sapiens (Human))	BDBM50357849 (CHEMBL1916108) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1ccc(cc21)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-9-23-7-6-14(10)18-25-12(3)17-11(2)24-15-5-4-13(19(20,21)22)8-16(15)26(17)18/h4-9H,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE3A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50357849 (CHEMBL1916108) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1ccc(cc21)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-9-23-7-6-14(10)18-25-12(3)17-11(2)24-15-5-4-13(19(20,21)22)8-16(15)26(17)18/h4-9H,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human))	BDBM50357849 (CHEMBL1916108) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1ccc(cc21)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-9-23-7-6-14(10)18-25-12(3)17-11(2)24-15-5-4-13(19(20,21)22)8-16(15)26(17)18/h4-9H,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE9A using [3H]cGMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50357849 (CHEMBL1916108) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1ccc(cc21)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-9-23-7-6-14(10)18-25-12(3)17-11(2)24-15-5-4-13(19(20,21)22)8-16(15)26(17)18/h4-9H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE7A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM50357849 (CHEMBL1916108) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1ccc(cc21)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-9-23-7-6-14(10)18-25-12(3)17-11(2)24-15-5-4-13(19(20,21)22)8-16(15)26(17)18/h4-9H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE1B using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50357849 (CHEMBL1916108) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1ccc(cc21)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-9-23-7-6-14(10)18-25-12(3)17-11(2)24-15-5-4-13(19(20,21)22)8-16(15)26(17)18/h4-9H,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Homo sapiens (Human))	BDBM50357849 (CHEMBL1916108) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1ccc(cc21)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-9-23-7-6-14(10)18-25-12(3)17-11(2)24-15-5-4-13(19(20,21)22)8-16(15)26(17)18/h4-9H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Bos taurus (Bovine))	BDBM50357849 (CHEMBL1916108) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1ccc(cc21)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-9-23-7-6-14(10)18-25-12(3)17-11(2)24-15-5-4-13(19(20,21)22)8-16(15)26(17)18/h4-9H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant bovine PDE6A using [3H]cGMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair