BDBM50357877 CHEMBL1916137

SMILES: Cc1nc(-c2ccncc2C)n2c1c(C)nc1c(F)cc(OCC(F)(F)F)cc21

InChI Key: InChIKey=XCTJCGBYOUBBCH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50357877   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50357877 (CHEMBL1916137) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1c(F)cc(OCC(F)(F)F)cc21 Show InChI InChI=1S/C20H16F4N4O/c1-10-8-25-5-4-14(10)19-27-12(3)18-11(2)26-17-15(21)6-13(7-16(17)28(18)19)29-9-20(22,23)24/h4-8H,9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50357877 (CHEMBL1916137) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1c(F)cc(OCC(F)(F)F)cc21 Show InChI InChI=1S/C20H16F4N4O/c1-10-8-25-5-4-14(10)19-27-12(3)18-11(2)26-17-15(21)6-13(7-16(17)28(18)19)29-9-20(22,23)24/h4-8H,9H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair