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SMILES: Cc1ccccc1-c1[n+]([O-])ccc2c(ccnc12)-c1ccc(F)cc1F

InChI Key: InChIKey=BSZQSLWNMVTKJT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50357886   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50357886
PNG
(CHEMBL1916344)
Show SMILES Cc1ccccc1-c1[n+]([O-])ccc2c(ccnc12)-c1ccc(F)cc1F |(26.55,-4.96,;27.88,-5.73,;27.89,-7.27,;29.22,-8.04,;30.56,-7.26,;30.55,-5.72,;29.22,-4.96,;29.21,-3.43,;27.88,-2.66,;26.54,-3.43,;27.88,-1.11,;29.21,-.34,;30.54,-1.11,;31.88,-.33,;33.22,-1.11,;33.22,-2.66,;31.87,-3.42,;30.54,-2.65,;31.88,1.2,;30.55,1.97,;30.54,3.5,;31.88,4.28,;31.88,5.82,;33.22,3.51,;33.22,1.97,;34.55,1.2,)|
Show InChI InChI=1S/C21H14F2N2O/c1-13-4-2-3-5-15(13)21-20-18(9-11-25(21)26)16(8-10-24-20)17-7-6-14(22)12-19(17)23/h2-12H,1H3
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n/an/a 68n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human p38alpha MAP kinase after 1 hr by FRET analysis

J Med Chem 54: 7899-910 (2011)


Article DOI: 10.1021/jm200975u
BindingDB Entry DOI: 10.7270/Q2MW2HKR
More data for this
Ligand-Target Pair