null

SMILES: COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc5cc(C)ccc5n4)ccc23)cc1

InChI Key: InChIKey=JIIIXMIQTKYOKR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50359056   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM50359056 (CHEMBL1922527) Show SMILES COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc5cc(C)ccc5n4)ccc23)cc1 Show InChI InChI=1S/C41H43N3O4S/c1-26-8-17-34-29(20-26)13-15-31(43-34)25-48-32-16-18-35-33(21-32)38(49-40(2,3)4)36(22-41(5,6)39(45)46)44(35)24-27-9-11-28(12-10-27)30-14-19-37(47-7)42-23-30/h8-21,23H,22,24-25H2,1-7H3,(H,45,46)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.88E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amira Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 15 mins by ELISA				J Med Chem 54: 8013-29 (2011) Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM50359056 (CHEMBL1922527) Show SMILES COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc5cc(C)ccc5n4)ccc23)cc1 Show InChI InChI=1S/C41H43N3O4S/c1-26-8-17-34-29(20-26)13-15-31(43-34)25-48-32-16-18-35-33(21-32)38(49-40(2,3)4)36(22-41(5,6)39(45)46)44(35)24-27-9-11-28(12-10-27)30-14-19-37(47-7)42-23-30/h8-21,23H,22,24-25H2,1-7H3,(H,45,46)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	148	n/a	n/a	n/a	n/a	n/a	n/a
Amira Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]-3-[5-(pyrid-2-ylmethoxy)-3-tert-butylthio-1-benzylindol-2-yl]-2,2-dimethylpropionic acid from FLAP in human polymorphonuclear ce...				J Med Chem 54: 8013-29 (2011) Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM50359056 (CHEMBL1922527) Show SMILES COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc5cc(C)ccc5n4)ccc23)cc1 Show InChI InChI=1S/C41H43N3O4S/c1-26-8-17-34-29(20-26)13-15-31(43-34)25-48-32-16-18-35-33(21-32)38(49-40(2,3)4)36(22-41(5,6)39(45)46)44(35)24-27-9-11-28(12-10-27)30-14-19-37(47-7)42-23-30/h8-21,23H,22,24-25H2,1-7H3,(H,45,46)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Amira Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA				J Med Chem 54: 8013-29 (2011) Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W
					More data for this Ligand-Target Pair