null

SMILES: COc1ccc(\C=C\C(=O)Nc2cccc(Oc3cc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)ncn3)c2)cc1OC

InChI Key: InChIKey=LIPSIDLSBZXGTC-GXDHUFHOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50360136   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50360136 (CHEMBL1928958) Show SMILES COc1ccc(\C=C\C(=O)Nc2cccc(Oc3cc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)ncn3)c2)cc1OC Show InChI InChI=1S/C34H28ClFN4O5/c1-42-30-12-9-22(16-31(30)43-2)10-14-33(41)40-25-7-4-8-27(17-25)45-34-19-32(37-21-38-34)39-26-11-13-29(28(35)18-26)44-20-23-5-3-6-24(36)15-23/h3-19,21H,20H2,1-2H3,(H,40,41)(H,37,38,39)/b14-10+	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of human ErbB2 preincubated for 2 hrs prior addition of ATP by HTRF assay				Bioorg Med Chem 20: 877-85 (2012) Article DOI: 10.1016/j.bmc.2011.11.056 BindingDB Entry DOI: 10.7270/Q2N29XCQ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50360136 (CHEMBL1928958) Show SMILES COc1ccc(\C=C\C(=O)Nc2cccc(Oc3cc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)ncn3)c2)cc1OC Show InChI InChI=1S/C34H28ClFN4O5/c1-42-30-12-9-22(16-31(30)43-2)10-14-33(41)40-25-7-4-8-27(17-25)45-34-19-32(37-21-38-34)39-26-11-13-29(28(35)18-26)44-20-23-5-3-6-24(36)15-23/h3-19,21H,20H2,1-2H3,(H,40,41)(H,37,38,39)/b14-10+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	523	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of human EGFR preincubated 2 hrs prior addition of ATP by HTRF assay				Bioorg Med Chem 20: 877-85 (2012) Article DOI: 10.1016/j.bmc.2011.11.056 BindingDB Entry DOI: 10.7270/Q2N29XCQ
					More data for this Ligand-Target Pair