BDBM50360570 CHEMBL1933172

SMILES: CN1CCC2(CC1)CNC(=O)c1cc([nH]c21)-c1ccnc(NC(=O)c2cccc(F)c2)c1

InChI Key: InChIKey=DODIBPZRZYINLL-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50360570   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50360570 (CHEMBL1933172) Show SMILES CN1CCC2(CC1)CNC(=O)c1cc([nH]c21)-c1ccnc(NC(=O)c2cccc(F)c2)c1 Show InChI InChI=1S/C24H24FN5O2/c1-30-9-6-24(7-10-30)14-27-23(32)18-13-19(28-21(18)24)15-5-8-26-20(12-15)29-22(31)16-3-2-4-17(25)11-16/h2-5,8,11-13,28H,6-7,9-10,14H2,1H3,(H,27,32)(H,26,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MK2 using Fluo-betaA-11A NeoMPS as substrate pre-incubated for 30 mins before substrate addition measured after 2 hrs by IMAP assay				Bioorg Med Chem Lett 22: 613-8 (2011) Article DOI: 10.1016/j.bmcl.2011.10.071 BindingDB Entry DOI: 10.7270/Q2RN389G
					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50360570 (CHEMBL1933172) Show SMILES CN1CCC2(CC1)CNC(=O)c1cc([nH]c21)-c1ccnc(NC(=O)c2cccc(F)c2)c1 Show InChI InChI=1S/C24H24FN5O2/c1-30-9-6-24(7-10-30)14-27-23(32)18-13-19(28-21(18)24)15-5-8-26-20(12-15)29-22(31)16-3-2-4-17(25)11-16/h2-5,8,11-13,28H,6-7,9-10,14H2,1H3,(H,27,32)(H,26,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	640	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MK2-mediated HSP27 phosphorylation in LPS-stimulated human THP1 cells pre-incubated for 60 mins prior to LPS-induction measured after 6...				Bioorg Med Chem Lett 22: 613-8 (2011) Article DOI: 10.1016/j.bmcl.2011.10.071 BindingDB Entry DOI: 10.7270/Q2RN389G
					More data for this Ligand-Target Pair