BDBM50360576 CHEMBL1933161

SMILES: Cc1ccc(cc1C)C(=O)Nc1nccc(n1)-c1cc2c([nH]1)C1(CCNCC1)CNC2=O

InChI Key: InChIKey=RQGMNVCQBKKPKI-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50360576   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50360576 (CHEMBL1933161) Show SMILES Cc1ccc(cc1C)C(=O)Nc1nccc(n1)-c1cc2c([nH]1)C1(CCNCC1)CNC2=O Show InChI InChI=1S/C24H26N6O2/c1-14-3-4-16(11-15(14)2)21(31)30-23-26-8-5-18(29-23)19-12-17-20(28-19)24(13-27-22(17)32)6-9-25-10-7-24/h3-5,8,11-12,25,28H,6-7,9-10,13H2,1-2H3,(H,27,32)(H,26,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.10	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MK2 using Fluo-betaA-11A NeoMPS as substrate pre-incubated for 30 mins before substrate addition measured after 2 hrs by IMAP assay				Bioorg Med Chem Lett 22: 613-8 (2011) Article DOI: 10.1016/j.bmcl.2011.10.071 BindingDB Entry DOI: 10.7270/Q2RN389G
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