BDBM50361416 CHEMBL1934380

SMILES: O=C1NC(=S)NC1=Cc1cc2cc(ccc2s1)-c1ccc2C(=O)OCc2c1

InChI Key: InChIKey=IMDJEWJYMDXIRU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50361416   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Perforin-1 (Homo sapiens (Human))	BDBM50361416 (CHEMBL1934380) Show SMILES O=C1NC(=S)NC1=Cc1cc2cc(ccc2s1)-c1ccc2C(=O)OCc2c1 |w:6.5,8.8| Show InChI InChI=1S/C20H12N2O3S2/c23-18-16(21-20(26)22-18)8-14-7-12-5-11(2-4-17(12)27-14)10-1-3-15-13(6-10)9-25-19(15)24/h1-8H,9H2,(H2,21,22,23,26)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair