BDBM50361562 CHEMBL1939488

SMILES: CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)COC)c2)ncc1Cl

InChI Key: InChIKey=ITBJAHYMMJZDJN-HXUWFJFHSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50361562   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50361562 (CHEMBL1939488) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)COC)c2)ncc1Cl |r| Show InChI InChI=1S/C27H29ClFN7O4/c1-27(2)11-20(33-21(37)13-40-4)25(39)34-19-10-14(8-9-16(19)27)32-26-31-12-17(28)23(36-26)35-22-15(24(38)30-3)6-5-7-18(22)29/h5-10,12,20H,11,13H2,1-4H3,(H,30,38)(H,33,37)(H,34,39)(H2,31,32,35,36)/t20-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50361562 (CHEMBL1939488) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)COC)c2)ncc1Cl |r| Show InChI InChI=1S/C27H29ClFN7O4/c1-27(2)11-20(33-21(37)13-40-4)25(39)34-19-10-14(8-9-16(19)27)32-26-31-12-17(28)23(36-26)35-22-15(24(38)30-3)6-5-7-18(22)29/h5-10,12,20H,11,13H2,1-4H3,(H,30,38)(H,33,37)(H,34,39)(H2,31,32,35,36)/t20-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50361562 (CHEMBL1939488) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)COC)c2)ncc1Cl |r| Show InChI InChI=1S/C27H29ClFN7O4/c1-27(2)11-20(33-21(37)13-40-4)25(39)34-19-10-14(8-9-16(19)27)32-26-31-12-17(28)23(36-26)35-22-15(24(38)30-3)6-5-7-18(22)29/h5-10,12,20H,11,13H2,1-4H3,(H,30,38)(H,33,37)(H,34,39)(H2,31,32,35,36)/t20-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
					More data for this Ligand-Target Pair