BDBM50361569 CHEMBL1939321

SMILES: CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(N)CC3(C)C)c2)ncc1Cl

InChI Key: InChIKey=HAFZQSVDZNBXHX-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50361569   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin receptor (Homo sapiens (Human))	BDBM50361569 (CHEMBL1939321) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(N)CC3(C)C)c2)ncc1Cl Show InChI InChI=1S/C24H25ClFN7O2/c1-24(2)10-17(27)22(35)31-18-9-12(7-8-14(18)24)30-23-29-11-15(25)20(33-23)32-19-13(21(34)28-3)5-4-6-16(19)26/h4-9,11,17H,10,27H2,1-3H3,(H,28,34)(H,31,35)(H2,29,30,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50361569 (CHEMBL1939321) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(N)CC3(C)C)c2)ncc1Cl Show InChI InChI=1S/C24H25ClFN7O2/c1-24(2)10-17(27)22(35)31-18-9-12(7-8-14(18)24)30-23-29-11-15(25)20(33-23)32-19-13(21(34)28-3)5-4-6-16(19)26/h4-9,11,17H,10,27H2,1-3H3,(H,28,34)(H,31,35)(H2,29,30,32,33)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50361569 (CHEMBL1939321) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(N)CC3(C)C)c2)ncc1Cl Show InChI InChI=1S/C24H25ClFN7O2/c1-24(2)10-17(27)22(35)31-18-9-12(7-8-14(18)24)30-23-29-11-15(25)20(33-23)32-19-13(21(34)28-3)5-4-6-16(19)26/h4-9,11,17H,10,27H2,1-3H3,(H,28,34)(H,31,35)(H2,29,30,32,33)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
					More data for this Ligand-Target Pair