Found 3 hits for monomerid = 50362146 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human)) | BDBM50362146
(CHEMBL1940665)Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(NCCSc2ccccc2)c(c1)[N+]([O-])=O |r| Show InChI InChI=1S/C32H31N5O7S2/c1-22(38)34-29(20-23-8-4-2-5-9-23)32(40)35-25-14-12-24(13-15-25)31(39)36-46(43,44)27-16-17-28(30(21-27)37(41)42)33-18-19-45-26-10-6-3-7-11-26/h2-17,21,29,33H,18-20H2,1H3,(H,34,38)(H,35,40)(H,36,39)/t29-/m0/s1 | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description Binding affinity to Mcl-1 by competitive fluorescence polarization assay |
Bioorg Med Chem Lett 22: 39-44 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.101 BindingDB Entry DOI: 10.7270/Q2MG7PX2 |
More data for this Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50362146
(CHEMBL1940665)Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(NCCSc2ccccc2)c(c1)[N+]([O-])=O |r| Show InChI InChI=1S/C32H31N5O7S2/c1-22(38)34-29(20-23-8-4-2-5-9-23)32(40)35-25-14-12-24(13-15-25)31(39)36-46(43,44)27-16-17-28(30(21-27)37(41)42)33-18-19-45-26-10-6-3-7-11-26/h2-17,21,29,33H,18-20H2,1H3,(H,34,38)(H,35,40)(H,36,39)/t29-/m0/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description Binding affinity to Bcl-2 by competitive fluorescence polarization assay |
Bioorg Med Chem Lett 22: 39-44 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.101 BindingDB Entry DOI: 10.7270/Q2MG7PX2 |
More data for this Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50362146
(CHEMBL1940665)Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(NCCSc2ccccc2)c(c1)[N+]([O-])=O |r| Show InChI InChI=1S/C32H31N5O7S2/c1-22(38)34-29(20-23-8-4-2-5-9-23)32(40)35-25-14-12-24(13-15-25)31(39)36-46(43,44)27-16-17-28(30(21-27)37(41)42)33-18-19-45-26-10-6-3-7-11-26/h2-17,21,29,33H,18-20H2,1H3,(H,34,38)(H,35,40)(H,36,39)/t29-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description Binding affinity to Bcl-xL by competitive fluorescence polarization assay |
Bioorg Med Chem Lett 22: 39-44 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.101 BindingDB Entry DOI: 10.7270/Q2MG7PX2 |
More data for this Ligand-Target Pair | |