BDBM50362217 CHEMBL1938978

SMILES: CN1C[C@H]2CN(C[C@H]2C1)C(=N)c1nc2c(F)c(F)c(F)cc2[nH]1

InChI Key: InChIKey=TYMUPJRAJQBISE-OCAPTIKFSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50362217   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM50362217 (CHEMBL1938978) Show SMILES CN1C[C@H]2CN(C[C@H]2C1)C(=N)c1nc2c(F)c(F)c(F)cc2[nH]1 |r| Show InChI InChI=1S/C15H16F3N5/c1-22-3-7-5-23(6-8(7)4-22)14(19)15-20-10-2-9(16)11(17)12(18)13(10)21-15/h2,7-8,19H,3-6H2,1H3,(H,20,21)/t7-,8+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...				Bioorg Med Chem Lett 22: 1156-9 (2012) Article DOI: 10.1016/j.bmcl.2011.11.098 BindingDB Entry DOI: 10.7270/Q2Q81DJD
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50362217 (CHEMBL1938978) Show SMILES CN1C[C@H]2CN(C[C@H]2C1)C(=N)c1nc2c(F)c(F)c(F)cc2[nH]1 |r| Show InChI InChI=1S/C15H16F3N5/c1-22-3-7-5-23(6-8(7)4-22)14(19)15-20-10-2-9(16)11(17)12(18)13(10)21-15/h2,7-8,19H,3-6H2,1H3,(H,20,21)/t7-,8+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...				Bioorg Med Chem Lett 22: 1156-9 (2012) Article DOI: 10.1016/j.bmcl.2011.11.098 BindingDB Entry DOI: 10.7270/Q2Q81DJD
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50362217 (CHEMBL1938978) Show SMILES CN1C[C@H]2CN(C[C@H]2C1)C(=N)c1nc2c(F)c(F)c(F)cc2[nH]1 |r| Show InChI InChI=1S/C15H16F3N5/c1-22-3-7-5-23(6-8(7)4-22)14(19)15-20-10-2-9(16)11(17)12(18)13(10)21-15/h2,7-8,19H,3-6H2,1H3,(H,20,21)/t7-,8+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to human histamine H3 receptor				Bioorg Med Chem Lett 22: 1156-9 (2012) Article DOI: 10.1016/j.bmcl.2011.11.098 BindingDB Entry DOI: 10.7270/Q2Q81DJD
					More data for this Ligand-Target Pair